AIF from Data

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Extract an Arterial Input Function (AIF) from a region of interest (ROI) in a dynamic contrast-enhanced MRI (DCE-MRI) dataset. This node calculates the AIF by averaging the contrast agent concentration over a set of selected voxels, defined by an input mask. The extracted AIF is then corrected for hematocrit to ensure accurate quantification of plasma contrast concentration.

This node is useful in DCE-MRI applications where a patient-specific AIF is required instead of using a predefined or population-based function. The AIF is essential for quantitative perfusion and pharmacokinetic modeling in MRI-based tracer kinetic studies.

Inputs

Concentration

The contrast agent concentration image from which the AIF is extracted.

Type: Image, Required, Single

AIF Voxels

A mask defining the region of interest (ROI) from which the AIF will be computed.

Type: Mask, Required, Single

Outputs

AIF

The extracted arterial input function (AIF) computed from the input data.

Type: Table

Settings

Hematocrit Float

The hematocrit value used to correct the extracted AIF. The AIF is divided by (1 - hematocrit).